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Carlton L. Gyles DMW., Ph.D
Carlton L. Gyles, DMV., Ph.D is a Professor at the Department of Pathobiology of the Ontario Veterinary College at the University of Guelph. He is a Microbiologist and former Dean of the Faculty of Graduate studies - 1981 to 1986; Group Leader of Escherichia coli Research team and Associate Network Director of Canadian Research Network on Bacterial Pathogens of Swine.
Dr. Gyles is one of the world's leading experts on E.coli. He discovered the E. coli heat-labile enterotoxin and E.coli plasmids with genes for enterotoxin that are drug resistant.
He cloned and sequenced the gene for E. Coli verotoxin 2e, to purify the endema disease toxin. He also developed a toxoid vaccine against edema diseases in pigs.
He has expertise in the pathogenesis of E. coli infections, vaccines against E. coli infections, E. coli enterotoxins and Shiga toxins, and genes that encode E. coli virulence factors. He participates in the molecular aspects of vaccine production, bacteriophages, and receptor blockade and the study of the virulence factors of K88-positive E. coli.
| Disease | E. coli categories | Localization |
|---|
| New-born diarrhea (0-1 wk) | ETEC | Small intestine |
| Young pig diarrhea (2-4 wks) | ETEC | Small intestine |
| Postweaning diarrhea (4-8 wks) | ETEC/AEEC | Small intestine |
| Edema disease (4-8 wks) | VTEC | Small intestine |
| Hemorrhagic gastro-enteritis (1-8 wks) | ETEC | Small intestine |
| Septicemia (0-4 wks) | SEPEC/ETEC | Systemic |
| Note: Enterotoxigenic E. coli |
Dr. Carlton Gyles has over 100 research publications in refereed journals, 17 book chapters and 3 books edited.
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